γ-Linolenic Acid methyl ester

Research use only, not for human use.

γ-Linolenic Acid methyl ester is a weak leukotriene B4 (LTB4) receptor antagonist.

γ-Linolenic Acid methyl ester is a weak leukotriene B4 (LTB4) receptor antagonist.

γ-Linolenic Acid methyl ester (1-4 μg/mL; 72 h) induces apoptosis in vitro A-549 lung cancer cell lines using SRB assay. However GLA is due to its action at the gene/oncogene level and by altering BCl-2 expression Apoptosis Analysis Cell Line:A-549 lung cancer cell line Concentration:1, 2, 3, and 4 μg/mL Incubation Time:72 hours; observed at 24 h, 48 h, and 72 h Result:Showed cytotoxicity potentially due to the induction of apoptosis of tumor cells by augmenting free radical generation only in the tumor cells but not normal cells.

γ-Linolenic Acid methyl ester decreases the hepatic triglycerides and histological evidence of fatty liver induced by EtOH.γ-Linolenic Acid methyl ester could significantly decrease levels of plasma total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), MDA, atherosclerosis index (AI) and liver TC, MDA, and increase levels of high density lipoprotein cholesterol (HDL-C) in both normal and hyperlipidemic rats. Animal Model:Hepatic pathol rats model induced by EtOH (male Sprague-Dawley rats, 250-300 g)Dosage:90 mL, 50-60 mLAdministration:Intraperitoneal injection; once daily; administrated 90 mL during day 1-5 and day 9, 50-60 mL during day 6-8 Result:Decreased the hepatic triglycerides of 25.6 mg/g compared with saline (40.2 mg/g) or olive oil (42.8 mg/g) treatment.Decreased liver index (the ratio of liver weight and body wight) in hyperlipidemic rats, but had no significant effect in normal rats.

Methyl gamma-linolenate

Immunology/Inflammation

LTR

LTB4

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16326-32-2

292.46

C19H32O2

>98% (HPLC)

DMSO: 100mg/ml (341.88 mM); dimethyl formamide: 100mg/ml (341.88 mM)

CCCCC/C=C\C/C=C\C/C=C\CCCCC(OC)=O

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(-20℃)

With Ice Pack

≥ 2 years